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- W2391452029 abstract "Objective To predict the early contrast induced nephropathy(CIN) by the change of serum cystatin C(CysC) and IL-6 in patients with acute coronary syndrome(ASC) who had undertaken percutaneous coronary intervention(PCI).Methods Totally 190 patients with ACS who had undertaken PCI were enrolled from September 2009 to August 2010 in our hospital.All patients were given low-osmolar and nonionic contrast media.CIN was diagnosed according to the traditional method.The patients′ serum creatinine(Cr) levels before PCI,and at the 12th hour,24t hour,and 48th hour after PCI were assayed.There were 20 patients who suffered from CIN among all the 190 patients and they were defined as CIN group,and 20 patients were randomly chosen out of the 170 patients concurrently without CIN as non-CIN group.The serum samples adopted before PCI,and at the 2nd hour,8th hour and 24th hour after PCI were examined for assays of serum cystatin C(CysC) by Immunoturbidimetry and interleukin(IL)-6 by ELISA.The results were compared.Results The levels of serum IL-6 adopted at the 2nd hour after PCI began to increase in CIN group(P0.05) and significantly rose at the 8th and 48th hour than that adopted before PCI(P0.05).The levels of serum IL-6 adopted at the 8th hour and 24th hour after PCI significantly increased in CIN group than in non-CIN group(P0.05).In CIN group,there was no significant difference between the level of CysC adopted before PCI and those adopted at the 2nd and 8th hour after PCI(P0.05),but there was a significant difference between the level of CysC adopted before PCI and that adopted at the 24th hour after PCI(P0.05).There was a significant difference in CysC value at the 24th hour after PCI between the CIN group and non-CIN group(P0.05).In CIN group the levels of serum IL-6 and CysC were positively correlated with that of Cr after PCI(P0.05).Conclusion In patients with ACS,the level of IL-6 significantly increases at the 8th hour and the level of CysC increases at the 24th hour after PCI,even earlier than serum Cr.IL-6 and CysC could be used as early indicators to predict CIN after PCI." @default.
- W2391452029 created "2016-06-24" @default.
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- W2391452029 date "2011-01-01" @default.
- W2391452029 modified "2023-09-24" @default.
- W2391452029 title "Interleukin-6 and Cystatin C as Early Indicators to Predict Contrast Induced Nephropathy" @default.
- W2391452029 hasPublicationYear "2011" @default.
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