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- W2391453052 abstract "To synthesize derivatives of 2-deoxy-2,3-dehydro-N-acetyl-8-O-sulfoneuraminic acid(Neu5Ac2en8-sulfate) and 2-deoxy-2,3-dehydro-N-acetyl-9-O-sulfoneuraminic acid(Neu5Ac2en9-sulfate),and compare their inhibitory activities towards sialidase,Neu5Ac2en8-sulfates were synthesized by using triphenylmethyl to protect the 9-hydroxy group and sulfurtrioxide trimethylamine complex as a sulfation agent.Neu5Ac2en9-sulfates were synthesized by using the same sulfation method after deprotection of 9-O-triphenylmethyl in an acidic solution.Seven new derivatives of 8-sulfate and 9-sulfate were synthesized,the preliminary test showed that all the seven compounds possessed sialidase inhibitory activities and the activities of the derivatives of Neu5Ac2en9-sulfate were stronger than those of Neu5Ac2en8-sulfate." @default.
- W2391453052 created "2016-06-24" @default.
- W2391453052 creator A5057044310 @default.
- W2391453052 date "2001-01-01" @default.
- W2391453052 modified "2023-09-25" @default.
- W2391453052 title "Syntheses of 2-Deoxy-2,3-Dehydro-N-Acetyl-8-O-and 9-O-Sulfoneuraminic Acid Derivatives and Their Sialidase Inhibitory Activities" @default.
- W2391453052 hasPublicationYear "2001" @default.
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