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- W2391454620 abstract "Objective To explore the effect of PPARα specific activator CS207 on biological activity of peroxisome proliferator-activated receptor α(PPARα) in senescent human endothelial cells derived form umbilical vein in order to provide important experimental basis for prevention of vascular diseases in the elderly.Mehtods Primary culture of human endothelial cells derived from umbilical vein was used.The DNA binding activity and mRNA expression of PPARα in human senescent endothelial cells treated with different concentrations of CS207 were determined by semi-quantitative reverse transcription polymerase chain reaction(sqRT-PCR) and electrophoretic mobility shift assay(EMSA).Results Compared with those in young endothelial cells,the expression of PPARα mRNA and DNA binding activity significantly desreased in senescent endothelial cells(P0.01).As the specific activator of PPARα,CS207 could reverse the age-related alteration of PPARα biological activity,and this effect was concentration-dependent.Conclusion As the specific activator of PPARα,CS207 could reverse the age-related decrease in PPARα biological activity in human senescent endothelial cells." @default.
- W2391454620 created "2016-06-24" @default.
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- W2391454620 date "2007-01-01" @default.
- W2391454620 modified "2023-09-27" @default.
- W2391454620 title "Effects of CS207 on biological activity of peroxisome proliferator-activated receptor α in senescent endothelial cells" @default.
- W2391454620 hasPublicationYear "2007" @default.
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