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- W2391465628 abstract "Objective To study the inhibitory effect of secoisolariciresinol diglusoside(SDG) on hyperplasia of prostate induced by testosterone in rats and clarify its mechanism.Methods Fifty male Wistar rats were randomly divided into control group,model groups,finasteride(1.0 mg·kg-1) group and SDG(1.2 and 0.4 g·kg-1) groups.The levels of NO,SOD,CAT,TNF-α,bFGF and IL-8 in prostate tissues were detected by ELISA method.Results Compared with control group,the levels of NO,SOD and CAT in prostate tissues of rats in model group were decreased(P0.01),and the levels of TNF-α,bFGF and IL-8 in model group were increased(P0.01).Compared with model group,the levels of SOD,CAT and NO in SDG 1.2 g·kg-1 group were increased(P0.01),and the levels of TNF-α,bFGF and IL-8 in SDG 1.2 g·kg-1 group were decreased(P0.01).Conclusion The mechanism of inhibitory effects of SDG on hyperplasia of prostate induced by testosterone may be concerned with enhancing the activity of antioxidase,clearing away free radical and decreasing the levels of TNF-α,bFGF and IL-8 in rats." @default.
- W2391465628 created "2016-06-24" @default.
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- W2391465628 date "2011-01-01" @default.
- W2391465628 modified "2023-09-27" @default.
- W2391465628 title "Inhibitory effect of secoisolariciresinol diglusoside on hyperplasia of prostate in rats and its mechanism" @default.
- W2391465628 hasPublicationYear "2011" @default.
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