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- W2391472904 abstract "Objective: by a case-controlled design,to investigate the effect of combined therapy using double filtration plasmapheresis (DFPP) and oral statins on severe hypercholesterolemia in resistant nephrotic syndrome (NS) . Methodology: Twenty two patients with severe hypercholesterolemia caused by resistant NS were enrolled in this study. They were divided into three groups as follow: 2 of them in the group receiving a single session of DFPP alone (DFPP group) ,8 in the group receiving a single session of DFPP combined with oral Atorvastatin (Combination group) ,and 12 in the group receiving oral Atorvastatin alone (Statins group) . Other treatments for primary disease and symptom-control remained unchanged. All patients were followed-up to 4 weeks. Results: The baseline levels of serum total cholesterol (TC) were ( 12. 7 ±1. 40) mmol/L in DFPP group,( 17. 1 ±4. 70) mmol/L in combination group,and ( 15. 4 ±5. 10) mmol / L in statins group ( P 0. 05) . Single session of DFPP decreased serum TC by ( 85. 8% ± 7. 20% ) ( P 0. 01) , accompanied with a decline of plasma immunoglobulin A ( IgA) ,M and fibrinogen ( P 0. 01) but not albumin or IgG. No remission was found in the all groups during 4 weeks follow-up. During the follow-up period,compared with baseline data,serum TC was 85. 9% at the 1 week,100% at the 2 week,and 134% at the end in DFPP group,serum TC was below 50% in the first 2 weeks,and 70. 2% at the end in combination group,and serum TC was around 81. 1% through the whole period in the statins group. The levels of serum TC were significantly lower than that in the other groups at the first two weeks ( P 0. 01 ) . Conclusion: Oral statin alone can only decline lipids slightly in patients with severe hypercholesterolemia due to resistant nephrosis,while combined therapy using DFPP plus oral statin can decrease lipids to a larger extent in these patients." @default.
- W2391472904 created "2016-06-24" @default.
- W2391472904 creator A5007054845 @default.
- W2391472904 date "2013-01-01" @default.
- W2391472904 modified "2023-09-23" @default.
- W2391472904 title "Treatment of severe hypercholesterolemia in resistant nephrotic syndrome: the effect of combined therapy using double filtration plasmapheresis and statins" @default.
- W2391472904 hasPublicationYear "2013" @default.
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