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- W2391488045 abstract "【Objective】 To investigate the effect of Roux-en-Y gastric bypass on the oxidative stress in the kidney of type 2diabetics rats. 【Methods】 Forty SD rats were randomly divided into normal control group(NC, n = 8) and diabetes model group, n =32, the diabetes model group were injected STZ(35 mg / kg), 30 rates were considered as the successful diabetes model. Then they were randomly divided into a diabetes control group(DC,n = 8),a diabetes sham operation group(DSO, n = 8), and a diabetes operation group(DO, n=14). The levels of fasting blood glucose( FBG) before and 8 weeks after operation were tested; serum AGE,24h urine 8-OHdG were detected after 8 weeks of the operation; glucagon like peptide-1(GLP-1) was measured before the operation and at 1th, 2th, 4th, 8th weeks after the operation; after 8 weeks of operation the kidney weighty index was measured. The activities of antioxidant enzymes in renal including total superoxide dismutase(TSOD), catalase(CAT), glutathioneperoxidase(GSH-PX) and aleicdialdehyde(MDA) were measured by chromatometry. Western blot analysis was employed to assess the protein expression of receptor of advance glycation end products(RAGE). 【Results】 The fasting blood glucose of diabetes operation group decreased from(12.48 ± 1.37) mmol / L to(5.45 ± 0.67) mmol / L;the fasting GLP-1 of diabetes operation group increased from(8.12 ± 1.54)pmol / L to(22.35 ± 0.79) pmol / L 8 weeks after the operation(P 0.05); the serum AGE, kidney tissue RAGE, 24h urine 8-OHdG, microalbuminuria( MAU), kidney weighty index and MDA increased significantly in the DC and DSO groups compared with the DO and NC groups, otherwise the activities of TSOD, GSH-Px, CAT decreased significantly(P 0.05). PAS dyeing indicates that glomerulus extracellular matrix accumulating in the DC and DSO groups, the DO and NC groups have no obvious alter.【Conclusion】 The Roux-en-Y gastric bypass surge protects the kidney through re-balancing the oxitive and anti- oxitive system." @default.
- W2391488045 created "2016-06-24" @default.
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- W2391488045 date "2014-01-01" @default.
- W2391488045 modified "2023-09-27" @default.
- W2391488045 title "Effects of Roux-en-Y Gastric Bypass on Oxidative Stress in Kidney of Rats with Type 2 Diabetics" @default.
- W2391488045 hasPublicationYear "2014" @default.
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