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- W2391490530 abstract "Objective:To study the effect of portal vein occlusion in various degrees at the several stages and the following res- toration portal vein flow on liver aminopherase and the changes of indexes for oxygen free radicals injury.Methods:40 healthy a- dults white Japanese rabbits were randomly divided into one controlled group and four experimental groups(according to portal vein half-clamping for 30 min,45 min and portal vein full-clamping for 30 min,45 min,divided into B1、C1、B2、C2 groups.). Each experimental group's blood samples were collected from caval vein on certain times:1h before operation,certain times by the end of portal vein occluded,30 min、60 min after relieved of portal vein blocking.The levels of glutamate-pyruvate transam- inase(ALT),glutamic oxalacetic transaminase(AST),lipoperoxide(LPO),glutathion peroxidase(GSH-Px)were measured and compared with controlled group.Results:The levels of which in group A at each stage were no difference,compared with controlled group,group B1,C1 did not change significantly;the levels of AST,LPO were significantly increased after portal vein occlusion relieved for 30 min,60 min in group B2 though there were no differences at 30 min with portal vein occlusion. The levels of ALT,AST were increased obviously at 45 min with portal vein occlusion and the LPO level also increased after portal vein occlusion relieved for 30 rain in group C2.In group B2 and C2,the GSH-Px levels decreased after portal vein occlu- sion relieved for 60 min.Conclusion:There were no significant affection on aminopherase and the indexes of oxygen free radicals within 45 min of portal vein half-occluded;There were less affection on them at 30 min with portal vein completely occluded, but we should pay attention to the reperfusion injury after reperfusion;Portal vein full-blocking for 45 min should be performed prudently." @default.
- W2391490530 created "2016-06-24" @default.
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- W2391490530 date "2007-01-01" @default.
- W2391490530 modified "2023-09-26" @default.
- W2391490530 title "Effect of Portal Vein Occlusion and the Following Restoration of Portal Vein Flow on Liver Function and the Changes of Indexes in Oxygen Free Radicals" @default.
- W2391490530 hasPublicationYear "2007" @default.
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