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- W2391496427 abstract "Objective To discuss the possible pathogenesis and biological base of qi deficiency syndrome in different pathological stages of myocardial ischemia of coronary heart disease(CHD).Methods The rat model of qi deficiency syndrome of CHD myocardial ischemia was established by applying left coronary ligation,and the information of TCM four examinations were collected generally and dynamically.The levels of interleukin-1(IL-1),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase-9(MMP-9) were detected by using enzyme-linked immunosorbent assay in the model group and sham-operation group.Results After the operation for 4 days and 45 days,the qi deficiency syndrome was determined in model group from macroscopic signs and physico-chemical indicators.After 4 days,the levels of TNF-α,IL-1 and IL-6 increased by,respectively,5.52%,16.45% and 43.95%(P0.05),and the levels of MMP-2 and MMP-9 had no significant changes(P0.05) in the model group compared with the sham-operation group in the same stage.After 45 days,the levels of MMP-2 and MMP-9 increased by,respectively,15.05% and 28.08%(P0.05),while the concentration of inflammatory factors decreased and the level of IL-6 restored to normal(P0.05).Conclusion The levels of inflammatory factors including TNF-α,IL-1 and IL-6 increased in the model of CHD myocardial ischemia 4 days after the operation,which showed that the inflammatory reaction dominated the pathogenesis in this stage.After 45 days,the main manifestations of qi deficiency syndrome were the changes of MMP-2 and MMP-9,indexes related to myocardial remodeling and cardiac dysfunction,while the levels of inflammatory factors restored to normal.The leading pathogenesis of qi deficiency syndrome is different in the different pathological stages of myocardial ischemia.The study on the mechanism will provide experimental base for the biological and basic research in TCM syndromes." @default.
- W2391496427 created "2016-06-24" @default.
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- W2391496427 date "2011-01-01" @default.
- W2391496427 modified "2023-09-28" @default.
- W2391496427 title "Pathogenesis of qi deficiency syndrome of CHD myocardial ischemia induced by left coronary ligation" @default.
- W2391496427 hasPublicationYear "2011" @default.
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