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- W2391527265 abstract "Objective To investigate expression of Survivin and mucin 2(MUC2),and their correlation with atrophic gastritis with intestinal metaplasia and gastric carcinoma. Methods 30 normal gastric mucosa,30 tissues with atrophic gastritis with intestinal metaplasia,41 tissues with gastric carcinoma were detected with immunohistochemistry. The expressions of survivin and MUC2 in tissue microarray were studied. Results Two normal gastric mucosa expressed Survivin(7. 14%),but MUC2 was not expressed in the normal gastric mucosa. The positive expression rate of survivin was 21. 43% and MUC2 was75. 00% in atrophic gastritis with intestinal metaplasia. The positive expression rate of Survivin was 77. 78%,MUC2 was13. 89% in gastric carcinoma. The positive expression rate of Survivin and MUC2 in different gastric mucosa was of statistical significance(P 0. 001). The expression of Survivin in gastric carcinoma showed statistically significant difference(P 0. 05) in different Lauren classification、depth of invasion and TNM categories. The expression of MUC2 in different Lauren classification,tumor differentiation was statistically significant difference(P 0. 05). The expression of Survivin and MUC2 in gastric carcinoma was not associated with gender,patients age,lymph node metastasis,tumor location,tumor size(P 0. 05). The expression of Survivin shows no obvious correlation with MUC2(r = 0. 215,P = 0. 209). Conclusion The expressions of survivin and MUC2 might play an important role in the development of gastric carcinoma." @default.
- W2391527265 created "2016-06-24" @default.
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- W2391527265 date "2014-01-01" @default.
- W2391527265 modified "2023-09-24" @default.
- W2391527265 title "Expression and significance of Survivin and MUC2 in human atrophic gastritis and gastric carcinoma" @default.
- W2391527265 hasPublicationYear "2014" @default.
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