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- W2391551685 abstract "Objective To observe the growth character of the mammary adult stem cells (MASCs) in vitro and to explore the development in vivo by mammary stem cells transplantation into nude mice.Methods MASCs were seperated by magnetic activated cell sorting (MACS) to culture in vitro. Thirty nude mice were divided into two groups randomly. MASCs and MCF-7 cells were injected subcutaneously respectively in the axilla of mice as MASCs group and control group. The body observation was done after operation and histological examination was conducted 6 weeks after operation.Results MASCs cultured in vitro differentiated into luminal epithelial cells and myoepithelial. There was significant difference in tissues between MASCs group and MCF-7 group. The similar lacteal glandular tube structure seen in the histologcial section did not form cancer nest tissue, was separated into several folials by connective tissue; and a great quantity of adipose tissue were be seen.Conclusions MASCs separated by MACS can induce nude mice to form mammary tissue analog, having characters of proliferation and differentiation, which provide a new method for the research of the formation and development of mammary gland." @default.
- W2391551685 created "2016-06-24" @default.
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- W2391551685 date "2007-01-01" @default.
- W2391551685 modified "2023-09-25" @default.
- W2391551685 title "Experimental study of characters of adult mammary stem cells in vitro and in vivo" @default.
- W2391551685 hasPublicationYear "2007" @default.
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