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- W2391553552 abstract "Objective Axis inhibitor(Axin) is an important negative regulator of the Wnt signal pathway and can bind with p53.Both Axin and p53 are promoters in apoptosis.This study is to investigate the relationship between Axin expression and p53 expression,their relationship with clinical pathology factors and patient prognosis.Methods Immunohistochemistry and Western blot were performed in 95 cases of human non-small cell lung cancer with complete follow-up records.Results The positive rate of Axin expression in cytoplasm of non-small cell lung cancer was 45.26%(43/95),lower than that in normal lung tissue.The expression of Axin was positively correlated with differentiation of non-small cell lung cancer(=0.012),negatively correlated with TNM stage and lymph node metastasis(0.05) and p53(mt,= 0.000).The prognosis of the patients with high expression of Axin was better than that of the patients with low expression of Axin.Conclusions The expression of Axin is negatively correlated with that of p53(mt) with better prognosis for the patients with high expression of Axin." @default.
- W2391553552 created "2016-06-24" @default.
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- W2391553552 date "2012-01-01" @default.
- W2391553552 modified "2023-09-28" @default.
- W2391553552 title "Expression and significance of Axin and p53 in human non-small-cell lung cancer" @default.
- W2391553552 hasPublicationYear "2012" @default.
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