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- W2391560629 abstract "Objective:To analyze the relationship between hypoxia-inducible factor-1α(HIF-1α)protein expression and cell proliferation as well as apoptosis in human laryngeal squamous cell carcinoma,and to evaluate their clinicopathological significance.Methods:Eighty-six cases of LSCC were analyzed about their clinical and pathological data.Immuohistochemical staining technique was undertaken for the detection of the expression of HIF-1α and Ki-67,and terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling for apoptosis in 86 LSCCs and 32 normal tissues.Results:In LSCCs,the positive expression rate of HIF-1α was higher than that in the laryngeal mucosa tissues(P 0.05).The positive expression rate of HIF-1α was correlated with TNM stage and lymph node metastasis(P0.05).The apoptotic index in HIF-1α positive group was significantly lower than that in HIF-1α negative group(P0.05).However,there was no significant difference between HIF-1α positive group and HIF-1α negative group in the proliferation index.Conclusions:HIF-1α might play an important role in the progression of laryngeal carcinoma,and could be used in predicting malignant transformation of normal mucous membranes.HIF-1α was overexpressed in LSCCs,which was significantly associated with apoptosis of tumor cells." @default.
- W2391560629 created "2016-06-24" @default.
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- W2391560629 date "2010-01-01" @default.
- W2391560629 modified "2023-09-28" @default.
- W2391560629 title "Expression of hypoxia-inducible factor-1α and its relationship to proliferation and apoptosis in laryngeal squamous cell carcinoma" @default.
- W2391560629 hasPublicationYear "2010" @default.
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