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- W2391566147 abstract "Aim To determine the role of cerebral lymphatic drainage pathway in the development of neural injury following subarachnoid hemorrhage (SAH).Methods SAH and cerebral lymphatic blockage (CLB) models in adult New Zealand rabbits were used.Cerebrospinal fluid (CSF) was obtained from experimental animals after 5 days of modeling and was added into cultured PC12 cells.The PC12 cells were randomly divided into blank control,normal control (with normal CSF),SAH with CSF,and SAH+CLB with CSF groups.After half an hour,1 hour,2 hours and 4 hours,the LDH leakage of PC12 cells into media was detected by chromatometry.Cystoskeletons of PC12 cells were observed by laser confocal microscope after immunofluorescence staining.Results Compared with normal control group,an increased LDH leakage was found in SAH with CSF group and SAH+CLB with CSF group.The increase was more obvious in SAH+CLB with CSF group than that in SAH with CSF group.Cystoskeleton did not alter with normal CSF.In SAH with CSF group and SAH+CLB with CSF group,cystoskeleton staining became weak in cytoplasm.Shortened axons and dendrons were found in the above groups.Apoptotic appearance of nucleus was also observed.The above changes in SAH+CLB with CSF group were severer than those in SAH with CSF group.Conclusion The results suggest that blockage of cerebral lymphatic drainage pathway deteriorates the damage of PC12 cells with CSF from SAH,indicating cerebral ischemic injury following SAH may be attenuated by improving this pathway." @default.
- W2391566147 created "2016-06-24" @default.
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- W2391566147 date "2010-01-01" @default.
- W2391566147 modified "2023-09-22" @default.
- W2391566147 title "Effects of cerebrospinal fluid from experimental subarachnoid hemorrhage of cervical lymphatic blockage on LDH leakage and cystoskeleton of PC12 cells" @default.
- W2391566147 hasPublicationYear "2010" @default.
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