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- W2391566249 abstract "To explore the expression of CXCR7 on hepatoma cells and the effect of CXCR7 on the proliferation,migration,and adhesion of the hepatoma cells in vitro. To preliminary study CXCR7 on the characteristics of hepatoma cell biology and therapeutic targets,as the possibility of liver cancer. The expression of CXCR4 and CXCR7 on HepG2 cells was detected with Reverse transcription-PCR and Western-blot. Proliferation of the HepG2 cells was detected by MTT,after they were blocked by anti- CXCR4, anti-CXCR7 respectively. The effect of anti-CXCR4 and anti-CXCR7 respectively on the chemotaxis of the hepatoma cells were detected by transwell chamber chemotaxis experiments. By the treatment of the anti-CXCR4,anti-CXCR7,to explore the adhesion of HepG2 cells on the HUVEC. The concentrations of CXCR4 and CXCR7 were expressed on HepG2 cells. Anti -CXCR7 abolished significantly the effects induced by CXCR7 on proliferation. The CXCR7 was no significant role in the migration of HepG2 cells. Both of anti-CXCR4 and anti-CXCR7 impacted on the adhesion of HepG2 cells in vitro, however,the anti-CXCR7 was more pronounced inhibitory effect than the anti-CXCR4. It is concluded that the SDF-1 plays a direct promoting role in proliferation,migration,and adhesion of the hepatoma cells. CXCR7 plays a different but synergistic role as compared with that of CXCR4. Anti-CXCR7 possibly abolished the induction,so that it is potential as a therapy target for liver cancer." @default.
- W2391566249 created "2016-06-24" @default.
- W2391566249 creator A5043696992 @default.
- W2391566249 date "2010-01-01" @default.
- W2391566249 modified "2023-09-28" @default.
- W2391566249 title "The Effect of CXCR7/SDF-1 on the Proliferation,Migration,and Adhesion of the Hepatoma Cells" @default.
- W2391566249 hasPublicationYear "2010" @default.
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