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- W2391567504 abstract "Objective:To investigate the effects of adrenaline on the expressions of TGF-β1,SR-A1 and CD36 mRNA in THP-1 macrophages.Methods:THP-1 macrophages were incubated with different concentrations of adrenaline for 24 hours,then the gene ex- pressions of TGF-β1,SR-A1 and CD36 were determined by RT-PCR.Levels of TGF-β1 in the supematants of cells were determined by enzyme-linked immunosorbent assay(ELISA).Western-blotting analysis was used to detect protein level of SR-A1.Results:When THP-1 macrophages were treated with 100 nmol/L and 1μmol/L adrenaline,the mRNA and protein levels of TGF-β1 decreased but the mRNA and protein levels of SR-A1 mRNA increased,and there was statistically significance compared with control(without adrenaline)(P0. 05).While THP-1 macrophages were treated with adrenaline from lpmol/L to 1μmol/L,there was no significant effect of CD36 gene ex- pression in each group(p0.05).Conclusion:Adrenaline could down-regulate TGF-β1 mRNA expression and up-regulate SR-A1 mRNA expression in THP-1 macrophages,which might be related to the genesis of Atherosclerosis(As)." @default.
- W2391567504 created "2016-06-24" @default.
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- W2391567504 date "2007-01-01" @default.
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- W2391567504 title "Effects of Adrenaline on TGF-β1,SR-A1 and CD36 Expression in THP-1 Macrophages" @default.
- W2391567504 hasPublicationYear "2007" @default.
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