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- W2391568611 abstract "OBJECTIVE:To study the relationship between genetic polymorphisms of growth hormone 1 (GH1) T1663A and the susceptibility of colorectal cancer (CRC). METHODS: A case control study was conducted with 315 patients with CRC and 439 population-based controls in Jiangsu Province, China. The epidemiological data were collected, and DNAs of peripheral blood leukocytes were obtained from all of the subjects. GH1 genotypes were detected by PCR-RFLP. RESULTS: 1) The frequencies of the GH1 T/T, T/A and A/A genotypes were 42.2%, 46.7% and 11.1% in colorectal cancer cases, and 38.1%, 45.9% and 16.0% in controls, respectively. Compared with individuals who had GH1 T/T genotype, individuals who had GH1 A/A genotype were at a decreased risk of developing colorectal cancer (sex-, age-, smoking-and alcohol drinking-adjusted OR=0.88, 95%CI: 0.78-0.99, P=0.029). 2) Smoking was not associated with the risk of colorectal cancer, whereas alcohol drinking was associated with the increased risk of colorectal cancer (sex-, age-, smoking- and GH1 genotype-adjusted OR=1.96, 95%CI: 1.34-2.86). 3) Among non-smokers, individuals who had GH1 A/A genotype were at a decreased risk of developing colorectal cancer (sex-, age-adjusted OR=0.50, 95%CI: 0.27-0.93) compared with individuals who had GH1 T allele. Among non-drinkers, individuals who had GH1 A/A genotype also were at a decreased risk of developing colorectal cancer (sex-, age-adjusted OR=0.56, 95%CI: 0.32-0.99) compared with individuals who had GH1 T allele. CONCLUSION: The results show that the GH1 gene T1663A polymorphism can influence susceptibility of colorectal cancer, particularly in non-smokers or non-drinkers." @default.
- W2391568611 created "2016-06-24" @default.
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- W2391568611 date "2006-01-01" @default.
- W2391568611 modified "2023-09-25" @default.
- W2391568611 title "Relationship between growth hormone Igenetic polymorphism and smoking,alcohol drinking and the susceptibility of colorectal cancer" @default.
- W2391568611 hasPublicationYear "2006" @default.
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