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- W2391569444 abstract "In this paper,we aimed to investigate the roles of antineutrophil cytoplasmic antibodies(ANCA) and their target antigens in patients with lupus nephritis(LN).The serum ANCA levels of 33 LN patients in activity and 20 healthy controls were detected by indirect immunofluorescence(IIF) and enzyme-linked immunosorbent assay(ELISA).Correlations between ANCA and clinical manifestations and other autoantibodies were also analyzed.Our results showed that 45.4% of the sera samples in LN patients were ANCA-positive and all of them were perinuclear ANCA;80.0% of sera samples with ANCA-positive were lactoferrin(LF) when recognized by ELISA,and their fluorescence model showed formaldehyde-sensitive type,while 20.0% of the sera samples with ANCA-positive were myeloperoxidase(MPO),and their fluorescence model displayed formaldehyde resistance type.Moreover,ANCA and their target antigens were not found in the serum of healthy controls.The age of ANCA-positive LN patients was significantly lower than that of ANCA-negative patients.Cutaneous vasculitis,disease activity,and anti ds-DNA antibody positive rates of ANCA-positive patients were significantly higher than those of ANCA-negative patients.However,there was no significant difference of pathology types between the two groups.The results above indicated that ANCA may play a pathogenetic role in LN." @default.
- W2391569444 created "2016-06-24" @default.
- W2391569444 creator A5045689266 @default.
- W2391569444 date "2012-01-01" @default.
- W2391569444 modified "2023-09-23" @default.
- W2391569444 title "Antineutrophil cytoplasmic antibodies and their target antigens in lupus nephritis" @default.
- W2391569444 hasPublicationYear "2012" @default.
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