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- W2391571570 abstract "OBJECTIVE To evaluate the efficacy and safety of pregabalin(PGB)for the patients with primary trigeminal neuralgia(PTN).METHODS 121 patients with PTN were randomly divided into PGB group(59 cases) and carbamazepine(CBZ) group(62 cases).Both groups were administered with low dose at first,then observed the therapeutic effect and adverse reactions until termination of the fourth week.The plasma SP and β-EP levels were detected by radioimmunoassay before administration,also at the termination,while the visual analogue scales(VAS) were measured.RESULTS The clinical efficiency of PGB was 89.8%,that of CBZ was 72.4%,which was significantly different between the two groups(P0.05).The treatments reduced plasma SP level while increasing plasma β-EP level in the 2 groups.The change of PGB group was more obvious than that of CBZ group(P0.05).The incidence rate of adverse reactions by PGB(30.5%,18/59) was less than that by CBZ(58.1%,36/62)(P0.05).CONCLUSION The efficacy and safety of PGB for the patients with PTN surpass that of CBZ." @default.
- W2391571570 created "2016-06-24" @default.
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- W2391571570 date "2013-01-01" @default.
- W2391571570 modified "2023-09-23" @default.
- W2391571570 title "Influence of pregabalin on plasma substance P and beta-endorphin in patients with trigeminal neuralgia" @default.
- W2391571570 hasPublicationYear "2013" @default.
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