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- W2391572195 abstract "Objective: To evaluate the plasminogen activator system in women with polycystic ovary syndrome(PCOS) and determine whether metformin would increase the plasminogen activation in PCOS patients.Methods:(1) Serum free-testosterone(F-T),insulin(INS),tissue plasminogen activator(t-PA),plasminogen activator inhibitor type-1(PAI-1) activity of thirty women with PCOS and twenty controls were measured.(2) F-T,INS,t-PA,PAI-1 were also measured before and after a month oral administration of metformin 750~1 500 mg daily in ten PCOS women with hyperinsulinism.Results: The women with PCOS had higher serum levels of insulin(±s):(24.42±12.30)(mU/L,)higher F-T(2.70±1.50)ng/L,lower t-PA(0.17±0.06)KU/L and higher PAI-1(0.88±0.05)AU/ml than controls(10.04±6.12)mU/L,(1.70 ±1.00)ng/L,(0.28±0.04)KU/L,(0.70±0.09)AU/ml,respectively.The indices of serum INS,F-T,(t-PA) and PAI-1 were significantly improved after one month of metformin administration in the PCOS patient with(hyperinsulinism.)Conclusion: The fibrolysis activity is lower in women with PCOS and could be improved by(metformin.)" @default.
- W2391572195 created "2016-06-24" @default.
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- W2391572195 date "2005-01-01" @default.
- W2391572195 modified "2023-09-25" @default.
- W2391572195 title "The plasminogen ability in women with polycystic ovary syndrome" @default.
- W2391572195 hasPublicationYear "2005" @default.
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