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- W2391574241 abstract "Objective To explore and compare the effect of transplantation of neural stem cells(NSCs) and gama aminobutyric acid(GABA)ergic neurons on temporal lobe epilepsy rats.Methods NSCs were isolated from embryonic 12 d SD rat and identified.Then the third generation of NSCs were induced and differentiated into GABAergic neurons.A total of 48 SD rats were randomly divided into 4 groups: control group,non-transplantation group,NSCs transplantation group and GABAergic neurons transplantation group.Four days after the rat models of temporal lobe epilepsy were established by kainic acid(KA),NSCs and GABAergic neurons were transplanted into the right hippocampus of KA rats respectively and the cells were labeled with 5-bromodeoxyuridine(BrdU).The effects were observed at 4 w,8 w,12 w after the transplantation.Results The number of pyramidal neurons in hippocampal CA3 area was the most in both NSCs transplantation group and GABAergic neurons transplantation group 8w after the transplantation.In both groups,the amount of neurons in hippocampal CA3 peaked at 8 w compared with the other two time points.And there were statistical differences in the amount of neurons in hippocampal CA3 among 4 groups 8 w after transplantation(P0.05).Conclusion CA3 pyramidal neurons in both transplantation groups count the most 8 w after the transplantation.And the therapeutic effect is better in NSCs transplantation group than in GABAergic neurons transplantation group." @default.
- W2391574241 created "2016-06-24" @default.
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- W2391574241 date "2011-01-01" @default.
- W2391574241 modified "2023-09-25" @default.
- W2391574241 title "Experimental study on the transplantation of neural stem cells and GABAergic neurons for the treatment of temporal lobe epilepsy in rats" @default.
- W2391574241 hasPublicationYear "2011" @default.
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