Matches in SemOpenAlex for { <https://semopenalex.org/work/W2391576617> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2391576617 abstract "Tetrodotoxin-resistant Nav1.5 Na+ channel has been considered as the cardiac sodium channel.Na+ currents with tetrodotoxin resistance(TTX-R) and Nav1.5/SCN5A mRNA have been observed in neurons,but the cDNA encoding the TTX-R Nav1.5 Na+ channels in human central nervous system(CNS) has not been identified.Nav1.5/SCN5A cDNA was first cloned from human brain cortex by using RT-PCR method.Two variants of Nav1.5/SCN5A were found and tentatively named hB1 and hB2.Full sequence of cDNA encoding the α-subunit of TTX-R Nav1.5 Na+ channel in human brain cortex was 6 201 nucleotides long and was designated hB1.The longest open reading frame of hB1(accession number EF629346) encodes 2 016 amino acid residues.Sequence analysis has indicated that hB1 is highly homologus with human cardiac Nav1.5/SCN5A with 98% amino acid identity.There are 28 different amino acids between them,with 7 of which locating in the region encoded by exon6A or exon6.Alternative splicing of exon18 was not found in the gene cloning of human brain Nav1.5/SCN5A,which was different from human heart Nav1.5/SCN5A,but a novel alternative splicing lacking exon24 was first found.The two variants were detected in similar ratio in brain,but they were proved to relate to age development in heart tissue.The exon24 of human Nav1.5/SCN5A has 54 nucleotides,encoding 30 amino acid residues,and are located in human chromosome 3P21.This alternative splicing was also found in other tissues other than heart and brain.The expression pattern of the two variants in different tissues was different when detected by competitive PCR method and it was also changing with age development.Furthermore,Nav1.5/SCN5A mRNA was detected in 16 different tissue types of Wistar rats(P80) by reverse polymerase chain reaction(RT-PCR) .These results suggest that Nav1.5 Na+ channels in human brain are encoded by new variants of Nav1.5/SCN5A and its mRAN is more widely expressed than previously thought.The study is useful for making further investigation in the functional analysis of Nav1.5 Na+ channels in different tissues." @default.
- W2391576617 created "2016-06-24" @default.
- W2391576617 creator A5076271869 @default.
- W2391576617 date "2007-01-01" @default.
- W2391576617 modified "2023-09-25" @default.
- W2391576617 title "Nav1.5 Na~+ Channels in Human Brain Are Encoded by New Variants of Nav1.5/SCN5A" @default.
- W2391576617 hasPublicationYear "2007" @default.
- W2391576617 type Work @default.
- W2391576617 sameAs 2391576617 @default.
- W2391576617 citedByCount "0" @default.
- W2391576617 crossrefType "journal-article" @default.
- W2391576617 hasAuthorship W2391576617A5076271869 @default.
- W2391576617 hasConcept C104317684 @default.
- W2391576617 hasConcept C134018914 @default.
- W2391576617 hasConcept C153911025 @default.
- W2391576617 hasConcept C167625842 @default.
- W2391576617 hasConcept C169760540 @default.
- W2391576617 hasConcept C178790620 @default.
- W2391576617 hasConcept C185592680 @default.
- W2391576617 hasConcept C187882448 @default.
- W2391576617 hasConcept C194583182 @default.
- W2391576617 hasConcept C2776741303 @default.
- W2391576617 hasConcept C2777670902 @default.
- W2391576617 hasConcept C36823959 @default.
- W2391576617 hasConcept C50952357 @default.
- W2391576617 hasConcept C515207424 @default.
- W2391576617 hasConcept C537181965 @default.
- W2391576617 hasConcept C54355233 @default.
- W2391576617 hasConcept C54458228 @default.
- W2391576617 hasConcept C67705224 @default.
- W2391576617 hasConcept C86803240 @default.
- W2391576617 hasConceptScore W2391576617C104317684 @default.
- W2391576617 hasConceptScore W2391576617C134018914 @default.
- W2391576617 hasConceptScore W2391576617C153911025 @default.
- W2391576617 hasConceptScore W2391576617C167625842 @default.
- W2391576617 hasConceptScore W2391576617C169760540 @default.
- W2391576617 hasConceptScore W2391576617C178790620 @default.
- W2391576617 hasConceptScore W2391576617C185592680 @default.
- W2391576617 hasConceptScore W2391576617C187882448 @default.
- W2391576617 hasConceptScore W2391576617C194583182 @default.
- W2391576617 hasConceptScore W2391576617C2776741303 @default.
- W2391576617 hasConceptScore W2391576617C2777670902 @default.
- W2391576617 hasConceptScore W2391576617C36823959 @default.
- W2391576617 hasConceptScore W2391576617C50952357 @default.
- W2391576617 hasConceptScore W2391576617C515207424 @default.
- W2391576617 hasConceptScore W2391576617C537181965 @default.
- W2391576617 hasConceptScore W2391576617C54355233 @default.
- W2391576617 hasConceptScore W2391576617C54458228 @default.
- W2391576617 hasConceptScore W2391576617C67705224 @default.
- W2391576617 hasConceptScore W2391576617C86803240 @default.
- W2391576617 hasLocation W23915766171 @default.
- W2391576617 hasOpenAccess W2391576617 @default.
- W2391576617 hasPrimaryLocation W23915766171 @default.
- W2391576617 hasRelatedWork W1502143215 @default.
- W2391576617 hasRelatedWork W1551396948 @default.
- W2391576617 hasRelatedWork W1616658513 @default.
- W2391576617 hasRelatedWork W1966956254 @default.
- W2391576617 hasRelatedWork W1972689226 @default.
- W2391576617 hasRelatedWork W1973670712 @default.
- W2391576617 hasRelatedWork W1974112901 @default.
- W2391576617 hasRelatedWork W1978533949 @default.
- W2391576617 hasRelatedWork W1979452119 @default.
- W2391576617 hasRelatedWork W2019092022 @default.
- W2391576617 hasRelatedWork W2021788605 @default.
- W2391576617 hasRelatedWork W2029826812 @default.
- W2391576617 hasRelatedWork W2044296578 @default.
- W2391576617 hasRelatedWork W2048000564 @default.
- W2391576617 hasRelatedWork W2048521308 @default.
- W2391576617 hasRelatedWork W2092211446 @default.
- W2391576617 hasRelatedWork W2096140407 @default.
- W2391576617 hasRelatedWork W2138629192 @default.
- W2391576617 hasRelatedWork W2188666777 @default.
- W2391576617 hasRelatedWork W2417285735 @default.
- W2391576617 isParatext "false" @default.
- W2391576617 isRetracted "false" @default.
- W2391576617 magId "2391576617" @default.
- W2391576617 workType "article" @default.