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- W2391582270 abstract "Objective To investigate the protective effect and cytosolic phospholipase A2(cPLA2) associated mechanism of panax notoginseng saponins(PNS) in spinal cord hemisection injured rats. Methods 55 adult Sprague-Dawley rats were randomly divided into three groups: sham group(n=5), spinal cord injury group(n=25) and PNS group(n=25). The rats were evaluated with BBB score, pathology and immunohistochemistry 1 d, 3 d, 7 d, 14 d and 21 d after intervention. Results Compared to the spinal cord injury group, motor recovery was significantly better in PNS group 3 d, 7 d, 14 d and 21 d after intervention(P0.05). Nissl staining showed less neuron necrosis and more integrated neural cells in morphology in PNS group 7 d, 14 d and 21 d after intervention. Cytosolic phospholipase A2(cPLA2) expression was inhabited, and less number of positive cells were found in PNS group 7 d, 14 d and 21 d after intervention. Conclusion PNS can inhibit the expression of cPLA2 after spinal cord injury, which may be one of the mechanisms of its effect on promoting motor recovery." @default.
- W2391582270 created "2016-06-24" @default.
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- W2391582270 date "2013-01-01" @default.
- W2391582270 modified "2023-09-24" @default.
- W2391582270 title "Protective Effect of Panax Notoginseng Saponins in Spinal Cord Hemisection Injured Rats" @default.
- W2391582270 hasPublicationYear "2013" @default.
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