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- W2391584090 abstract "Objective:To observe the influence of acute pulmonary injury induced by adriamycin(ADM) on β-defensin-2(BD-2) gene expression in rats.Methods:Forty male Sprague-Dawley rats were randomly divided into four groups:low dose ADM group,medium dose group,high dose group and control group.The ADM groups were administered ADM of different doses(10,20 and 40 mg·kg-1·d-1).Meanwhile,normal saline was given to the control group.All the rats were killed three days later,and the lung tissues were removed by thoracotomy.The expression of BD-2 at mRNA level was determined by RT-PCR analysis.Results:The level of BD-2 gene expression in medium-dose and high-dose groups was up-regulated significantly compared with that in the control group(P0.01);and the difference had no statistical significance between the low-dose group and the control(P0.05).Conclusions:The level of BD-2 gene is up-regulated in the lung tissues of rats with acute pulmonary injury induced by ADM." @default.
- W2391584090 created "2016-06-24" @default.
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- W2391584090 date "2009-01-01" @default.
- W2391584090 modified "2023-09-28" @default.
- W2391584090 title "Expression of β-defensin-2 gene in the lung tissue of rats intoxicated by adriamycin" @default.
- W2391584090 hasPublicationYear "2009" @default.
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