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- W2391604155 abstract "Objective:To investigate the optimal technological protocol and to observe the efficacy and morbidity of transperineal 125I seed implantation guided by ultrasound in prostate cancer.Methods:Thirty nine patients treated with transperineal 125I seed brachytherapy guided by transrectal ultrasound and real time TPS.The MPD of seed implantation was 140-160Gy.The activity of each seed was 0.35-0.50mCi.The median number of seeds was 69(19-97).Analysis was done after 1 month by pelvic CT scan.Biochemical failure was defined as elevations and ≥4ng/ml of PSA level after it reached nadir.Results:All 39 patients received 125I seed implantation under ultrasound guidance succesefully,36 patients achieved biochemical disease-free survival(BDFS),the PSA increased for 3 patients after seed implant on 6,8 and 36 month.The BDFS of 2 years and 3 years was 94.8% and 92.3% respectively.One patient received external beam radiation therapy,3 patients received hormone therapy.The rectum side effect of grade ⅠandⅡ was 5.1% and 7.7% respectively,the urinary complications of grade Ⅰ,Ⅱ and Ⅲ were 53.8%,17.9% and 2.6% respectively.The seed immigrant happened in 2 patients.Most of these symptoms were mild to moderate in severity and can be effectively managed by appropriate medication.Conclusion:Interstitial permanent brachytherapy with real time TPS is safe,convenient,minimally invasive,low urinary and rectal side effect." @default.
- W2391604155 created "2016-06-24" @default.
- W2391604155 creator A5091108483 @default.
- W2391604155 date "2009-01-01" @default.
- W2391604155 modified "2023-09-25" @default.
- W2391604155 title "Transperineal ultrasound guided ~(125)I seed implantation combined with endocrinotherapy for stage T_1-T_2 prostate cancer" @default.
- W2391604155 hasPublicationYear "2009" @default.
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