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- W2391639402 abstract "Objective This study was designed to investigate the effect and mechanism of Xueshuantong(XST) injection on rat intestinal ischemia-reperfusion(I/R) injury. Methods 30 Rats were randomly divided into three groups: sham-operated, I/R control, XST-treated.The superior mesenteric artery was occluded for 60 min and then allowed 60 min of reperfusion, except in the sham -operated group. The XST -treated group received 7ml/kg body weight XST injection intravenous 15 min before reperfusion. After 60 min of reperfusion, mean arterial blood pressure (MABP) and hemorrhagic degree of intestinal mucosa were observed,plasma nitric oxide (NO) contents were measured, and intestinal tissue samples were obtained for the determination of wet/ dry ratio, malondiadehyde(MDA) contents, superoxide dismutase(SOD) activities. Results The values of MABP and plasma NO contents were significantly lower,wet/dry ratio, MDA contents were significantly higher,intestinal mucosal lesions were significantly severe in the I/R control group than those in the sham-operated group(P0.01). XST injection significantly attenuated decrease of MABP and intestinal mucosal lesions, as compared with the I/R control group.Plasma NO contents were significantly higher,wet/dry ratio and MDA contents were significantly lower in the XST-treated group than those in the I/R control group(P0.01).Conclusions XST injection possesses the protective effect on rat intestinal I/R injury. The possible explanation for the action is inhibition of lipid peroxidation and increased NO content." @default.
- W2391639402 created "2016-06-24" @default.
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- W2391639402 date "2002-01-01" @default.
- W2391639402 modified "2023-09-25" @default.
- W2391639402 title "Effect of Xueshuantong Injection on Rat Intestinal Ischemia-Reperfusion Injury" @default.
- W2391639402 hasPublicationYear "2002" @default.
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