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- W2391658081 abstract "Objective To investigate the effects of nicotine on the growth and TrkA expression of cultured primitive rat basal forebrain cholinergic neurons. Methods Primitive rat basal forebrain neurons were cultured and evaluated . Morphologic, celluar vigor and TrkA expressing changes were observed by microscop , MTT assay,RT-PCR and immunocytochemistry respectively when the neurons were exposed to nicotine with different ending concentrations(0.01, 0.1, 1, 10, 100 μmol/L) . Results Being exposed to nicotine for 48 h, the neurons showed significant changes in morphology and cellular vigar, and average process quantity of the neurons, average process length and the length of the longest peocess of neurons were increased significantly. The results of MTT assay showed that average OD values were significantly increased. The expression of TrkA in the cultured neurons were increased after the neurons being exposed to nicotine with above four concentrations for 48 h, and the expression were decreased after being exposed to 100 μmol/L nicotine for 48 h. When the neurons were cultured with 10 μmol/L nicotine for different duration (8 h, 24 h, 48 h respectively),the above indexes were increased by time dependency. Conclusion Nicotine may have nutritive effect on rat cholinergic basal forebrain neurons in some extent. It may increase average process quantity of neurons, average process length and the length of the longest peocess, augmenting cellular vigor and increasing expression of TrkA." @default.
- W2391658081 created "2016-06-24" @default.
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- W2391658081 date "2004-01-01" @default.
- W2391658081 modified "2023-09-26" @default.
- W2391658081 title "Effects of nicotine on the growth and the TrkA expression of cultured primitive rat basal forebrain cholinergic neurons" @default.
- W2391658081 hasPublicationYear "2004" @default.
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