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- W2391661027 abstract "Objective:To evaluate the effect of triple dose China-made Gd-DTPA examinations on the detection of metastatic brain lesions based on lesion size.Methods:70 patients with intracranial metastases were studied prospectively with triple dose(0.3 mmol/kg)China-made Gd-DTPA.Precontrast studies were performed,followed by intravenous injection of 0.1 mmol/kg of Gd-DTPA.T 1-weighted images were acquired immediately after and at 20 minutes after injection.At 30 minutes an additional 0.2 mmol/kg of Gd-DTPA was administered(0.3 mmol/kg cumulative dose),and T 1-weighted images were acquired immediately and 20 minutes later.MR findings were analyzed qualitatively and quantitatively.Results:A significant greater number of lesions was seen on the high-dose as opposed to the standard-dose images(86→363,Ρ0.01).There was no significant difference in the detection rate for lesions larger than 10 mm between the triple dose contrast images and the other images.Lesions smaller than 10 mm had improved detection with triple dose images (Ρ0.05),especially for the lesions smaller than 5 mm,89.8～97.8% of them were demonstrated in triple dose contrast images,whereas only 0.5～0.9% of them were detected in the conventional contrast images(Ρ0.01).Conclusion:Triple dose contrast studies provide improved lesion detectability over studies performed in the same patients with a 0.1 mmol/kg dose and aid in patient diagnosis and treatment.It appears to be particularly more effective than standard dose imaging to demonstrate the lesions smaller than 5 mm. [" @default.
- W2391661027 created "2016-06-24" @default.
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- W2391661027 date "2001-01-01" @default.
- W2391661027 modified "2023-09-23" @default.
- W2391661027 title "Evaluation of Intracranial Metastases with China-made Gd-DTPA Contrast Enhancement MRI" @default.
- W2391661027 hasPublicationYear "2001" @default.
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