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- W2391667170 abstract "Objective: To study function of neutrophils and macrophages in mice with mixed infection by Escherichia coli and Candida albicans. Methods:Animal models with infection by E.coli or C.albicans alone or with mixed infection by two pathogens were established. Polymyxin B was used to neutralize toxic and immunogenic effects of lipopolysaccharide. Neutrophils and macrophages were isolated from mice of different groups. Adherence and phagocytosis function of neutrophils and killing function of macrophages were examined, and TNF α level released by macrophages was detected by ELISA. Results:Adherence rate of neutrophils in mice with mixed infection of these two pathogens was significantly higher than that in mice infected by E. coli or C. albicans alone (P0.05), while phagocytosis rate was significantly lower than that in mice with either infection alone(P0.05). Killing rate of macrophges in mice with mixed infection was significantly lower than that in mice with either infection alone(P0.05). TNF α level released by macrophages in mice with mixed infection was significantly higher than that in mice with either infection alone(P0.05). Conclusions:Function of neutrophils and macrophages is depressed in mice with concurrent E. coli and C. albicans infection, and host immunity can be affected by excessive production of TNF α by macrophages." @default.
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- W2391667170 date "2004-01-01" @default.
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- W2391667170 title "Study on function of neutrophils and macrophages in mice with concurrent Escherichia coli and Candida albicans infection" @default.
- W2391667170 hasPublicationYear "2004" @default.
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