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- W2391674469 abstract "Objective To investigate the potential role of tumor necrosis factor-alpha (TNF-α) in apoptosis after combined liver and kidney transplantation in rats. Methods Eighty rats which had combined liver and kidney transplantation were randomly paired, were divided into study group (n=20) and control group (n=20). 40 ml of 4 ℃ sodium chloride and anti-TNF-α monoclonal antibody (30 ml was infused from portal veins to donated livers and 10 ml from renal arteries to donated kidneys) were infused to the study group (0.1 mg/kg weight),and the same quantity of 4 ℃ sodium chloride was infused the control group. Venous blood was drew at different phases after the transplantations to detect the function of kidney and liver. The level of TNF-α and the cell apoptosis were detected in the transplanted tissues of liver and kidney by ELISA and terminal deoxynucleotidy transferase mediated dTUP-biotin nick-end labeling (TUNEL). Results The levels of AST, ACT, Cr and BUN in the study group were significantly lower than those of the control group at the same phases (P0.05). The level of TNF-α in the transplanted tissues of kidney and liver was also significantly lower as compared with those of control group. The cell apoptosis index of the transplanted tissues of kidney and liver was significantly smaller in the study group (P 0.05). There was no dramatically pathological change in the tissues of transplanted kidney and liver, which were treated with anti-TNF-α monoclonal antibody, and the structures are almost normal. Conclusion Anti-TNF-α monoclonal antibody may reduce cell apoptosis and accelerate the restoration of function of liver and kidney after combined liver and kidney transplantation." @default.
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- W2391674469 date "2006-01-01" @default.
- W2391674469 modified "2023-09-26" @default.
- W2391674469 title "Role of Tumor Necrosis Factor-Alpha Monoclonal Antibody in Cell Apoptosis after Combined Liver and Kidney Transplantation in Rats" @default.
- W2391674469 hasPublicationYear "2006" @default.
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