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- W2391691578 abstract "To observe the ultrastructure of nasal mucosa from mice with rhinitis allergic to dust mites with the potential to evaluate the effectiveness of dust mites vaccine immune therapy.24 BALB/c mice were randomly dividedinto 3 groups including negative control group(group A),allergic rhinitis group(group B) and dust mites vaccine treated group(group C).Mice rhinitis models allergic to dust mites were established by using the conventional method in our laboratory.The allergic symptoms including scratching nose,running nose and sneezing were observed after challenge.After being sacrificed by anesthesia at 24 h time point,the orbital blood were harvested for quantifying serumal specific IgE,IgG and IgG2a antibodies by using ELISA and right lower pulmonary tissues were dissected and treated for electron microscopy.Both group B and C manifested typical sneezing,runny nose and nose-scratching symptoms before treatment and the former symptoms reduced significantly after dust mites vaccine therapy,in contrasct no behavior abnormalities was observed in group A.Compared with group B,in group C,the content of serumal specific IgE antibody to Der f significantly decresed whereas those of IgG1 and IgG2a increased significantly(P0.05).Electron microscopy showed that in(1) group A,olfactory epithelial cells with integrate basement membrane regularly aligned on which surface abundant cilia covered regularly and in whose cytoplasm various organelles were scattered including ribosomes,mitochondria and rough endoplasmic reticulum in the cytoplasm;in(2) group B swelled olfactory epithelial cells with disordered basement membrane irregularly aligned on which surface rared cilia covered,in whose cytoplasm degenerated and vacuolize organelles,irregular,deformed and shrinked nucleus distributed,and among which inflammatory cells infiltrated,and in(3) group C,olfactory epithelial cilia aligned regularly with more uniform size though the density of cilia was lower than that of normal control group,the featured 9+2 structure of microtubules was distinct and the narrowed and densed mitochondria increased compared with that in control group.Dust mites vaccine can effectively improve the symptoms of allergic rhinitis,suppress the inflammatory changes in allergic rhinitis which paved a solid theoretical foundation for further study of dust mites vaccine therapy in allergic rhinitis." @default.
- W2391691578 created "2016-06-24" @default.
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- W2391691578 date "2011-01-01" @default.
- W2391691578 modified "2023-09-26" @default.
- W2391691578 title "The Electron Microscopy of Murine Nasal Mucosa with Allergic Rhinitis Treated with Dust Mites Vaccine" @default.
- W2391691578 hasPublicationYear "2011" @default.
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