Matches in SemOpenAlex for { <https://semopenalex.org/work/W2391702302> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2391702302 endingPage "9" @default.
- W2391702302 startingPage "387" @default.
- W2391702302 abstract "The clearance of intrahepatic hepatitis B virus (HBV) is mainly by the cytotoxicity of immune cells with ways including CD95 ligand/CD95 induction. We found that the liver cells do express CD95 ligand (CD95L), a cytotoxic cell surface molecule. This paper studied the mechanism and implications of the hepatocytes themselves to clear the virus.The HepG2 cells with induced CD95L and the HepG2.2.15 cells with constitutive CD95 expression were coincubated. The apoptotic cells were examined under fluorescence microscope and with flow cytometry.In chronic hepatitis B intrahepatic expressions of CD95L and/or CD95 were detected at both mRNA and protein level. Methotrexate induced CD95L expression of HepG2 cell. The HepG2 cells with CD95L could kill the HepG2.2.15 cells with CD95 molecule with apoptotic rates of 16.5% at 24h and 43.0% at 48h. This apoptosis effect could be blocked by using anti-CD95L antibody.The hepatocyte might induce apoptosis mutually and clear the virus themselves with a nonimmune mechanism." @default.
- W2391702302 created "2016-06-24" @default.
- W2391702302 creator A5033391350 @default.
- W2391702302 creator A5049286118 @default.
- W2391702302 creator A5056401596 @default.
- W2391702302 date "1999-06-01" @default.
- W2391702302 modified "2023-09-23" @default.
- W2391702302 title "[Clearance of intrahepatic hepatitis B virus by a nonimmune mechanism]." @default.
- W2391702302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11798673" @default.
- W2391702302 hasPublicationYear "1999" @default.
- W2391702302 type Work @default.
- W2391702302 sameAs 2391702302 @default.
- W2391702302 citedByCount "0" @default.
- W2391702302 crossrefType "journal-article" @default.
- W2391702302 hasAuthorship W2391702302A5033391350 @default.
- W2391702302 hasAuthorship W2391702302A5049286118 @default.
- W2391702302 hasAuthorship W2391702302A5056401596 @default.
- W2391702302 hasConcept C153911025 @default.
- W2391702302 hasConcept C154317977 @default.
- W2391702302 hasConcept C159047783 @default.
- W2391702302 hasConcept C190283241 @default.
- W2391702302 hasConcept C202751555 @default.
- W2391702302 hasConcept C203014093 @default.
- W2391702302 hasConcept C2522874641 @default.
- W2391702302 hasConcept C2776200302 @default.
- W2391702302 hasConcept C2780593183 @default.
- W2391702302 hasConcept C3031857 @default.
- W2391702302 hasConcept C31573885 @default.
- W2391702302 hasConcept C553184892 @default.
- W2391702302 hasConcept C55493867 @default.
- W2391702302 hasConcept C66008609 @default.
- W2391702302 hasConcept C71924100 @default.
- W2391702302 hasConcept C86803240 @default.
- W2391702302 hasConcept C8891405 @default.
- W2391702302 hasConceptScore W2391702302C153911025 @default.
- W2391702302 hasConceptScore W2391702302C154317977 @default.
- W2391702302 hasConceptScore W2391702302C159047783 @default.
- W2391702302 hasConceptScore W2391702302C190283241 @default.
- W2391702302 hasConceptScore W2391702302C202751555 @default.
- W2391702302 hasConceptScore W2391702302C203014093 @default.
- W2391702302 hasConceptScore W2391702302C2522874641 @default.
- W2391702302 hasConceptScore W2391702302C2776200302 @default.
- W2391702302 hasConceptScore W2391702302C2780593183 @default.
- W2391702302 hasConceptScore W2391702302C3031857 @default.
- W2391702302 hasConceptScore W2391702302C31573885 @default.
- W2391702302 hasConceptScore W2391702302C553184892 @default.
- W2391702302 hasConceptScore W2391702302C55493867 @default.
- W2391702302 hasConceptScore W2391702302C66008609 @default.
- W2391702302 hasConceptScore W2391702302C71924100 @default.
- W2391702302 hasConceptScore W2391702302C86803240 @default.
- W2391702302 hasConceptScore W2391702302C8891405 @default.
- W2391702302 hasIssue "6" @default.
- W2391702302 hasLocation W23917023021 @default.
- W2391702302 hasOpenAccess W2391702302 @default.
- W2391702302 hasPrimaryLocation W23917023021 @default.
- W2391702302 hasRelatedWork W1777103587 @default.
- W2391702302 hasRelatedWork W1969743834 @default.
- W2391702302 hasRelatedWork W2165013436 @default.
- W2391702302 hasRelatedWork W2335526988 @default.
- W2391702302 hasRelatedWork W2347541388 @default.
- W2391702302 hasRelatedWork W2391702302 @default.
- W2391702302 hasRelatedWork W2414650372 @default.
- W2391702302 hasRelatedWork W2745845876 @default.
- W2391702302 hasRelatedWork W2741620907 @default.
- W2391702302 hasRelatedWork W308714033 @default.
- W2391702302 hasVolume "38" @default.
- W2391702302 isParatext "false" @default.
- W2391702302 isRetracted "false" @default.
- W2391702302 magId "2391702302" @default.
- W2391702302 workType "article" @default.