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- W2391703171 abstract "Objective:To determine the relation of microvessel density (MVD) and the expression of vascular endothelial growth factor (VEGF) with the prognosis of axillary node negative breast carcinoma (ANNBC) for searching for new prognostic factors.Methods:Eighty specimens resected from patients with ANNBC were investigated by staining with a monoclonal antibody against FVⅢ RA and polyclonal antibody against VEGF. Correlations between the expression of VEGF,MVD and several of clinicopathologic factors were studied.Results:The mean of MVD was 35 99±20 27 in all patients.The positive rate of VEGF was 36 25%.Both of them were not correlated with the clinicopathological factors. MVD was significantly higher in VEGF positive tumors or relapsed or metastatic group than in VEGF negative tumors or disease free survival group. Moreover, patients with higher MVD or VEGF positive tumors had lower disease free survival (DFS) or overall survival (OS) than those with lower MVD or VEGF negative tumors. When those (45 cases) without adjuvant therapies after surgery were analyzed, the results were the same.But OS of them (35 cases) with adjuvant therapies had no significiant difference between high and low MVD group, and between VEGF positive and negative group.DFS was the same among VEGF positive and negative group. Multivariate analysis indicated that MVD, the expression of VEGF and tumor size were independent prognostic factors in patients with ANNBC. Conclusions:MVD, the expression of VEGF may be good prognostic indicators for patients with ANNBC and adjuvant therapies after surgery or antiangiogenic therapy may be useful to improve the prognosis of patients with high MVD or VEGF positive tumors." @default.
- W2391703171 created "2016-06-24" @default.
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- W2391703171 date "1999-01-01" @default.
- W2391703171 modified "2023-09-25" @default.
- W2391703171 title "Prognostic significance of microvessel density and the expression of vascular endothelial growth factor in axillary node negative breast cancer" @default.
- W2391703171 hasPublicationYear "1999" @default.
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