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- W2391706233 abstract "Objective To explore the influence of p38MAPK peculiar inhibitor SB203580, at different time and with different concentration, on renal function, apoptosis, p38MAPK activity, express quantity and p38MAPK substrate in the course of renal ischemic/reperfusion injury. Methods Forty-nine rats were randomly divided into 7 groups and each group 7 rats according to the different time of ischemic/reperfusion injury and medication. Based on the orthogonal square Latin table, identical milliliter number but different dosages of SB, were injected, in caudal vein, reaching different density in the rat body. BUN , Scr and apoptosis were detected. The qualitative and half quantitative analyses for protein were done by Western blot. Results SB could significantly alleviate rat renal ischemic/reperfusion injury, decrease BUN, Scr, renal tubular epithelial apoptosis and the activation of p38MAPK. But there was the difference of model, dosage and medication occasion(P0.05). A better effect could be acquired if 5 μmol/L of SB was injected 3 h before renalischemia. Conclusion SB can alleviate rat renal ischemic/reperfusion injury conspicuously if injection of SB before 3 h ischemia, and making blood medicine cncentration to be about 5 μmol/L." @default.
- W2391706233 created "2016-06-24" @default.
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- W2391706233 date "2004-01-01" @default.
- W2391706233 modified "2023-09-26" @default.
- W2391706233 title "Experimental study on the influence of SB203580 on cell apoptosis and p38MAPK in renal ischemic/reperfusion injury" @default.
- W2391706233 hasPublicationYear "2004" @default.
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