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- W2391711668 abstract "Objective To compare the difference of hepatic liver X receptor α (LXRα) and estrogen receptor α (ERα) expression between female cholesterol gallstone patients and gallstone-free controls. Methods Gene expression of LXRα, ERα and canalicular membrane transporters (ABCG5, ABCG8, ABCB11 and ABCB4) were assayed by real-time PCR between 11 female cholesterol gallstone patients and 10 female gallstone-free controls. Results LXRα increased 31% in the gallstone patients in comparison with gallstone-free controls (P0.05). ERα increased 35% in the gallstone patients without significance in comparison with controls (P0.05). Both ABCG5 and ABCG8 increased significantly in the gallstone patients. Neither of ABCB11 and ABCB4 differed between the two groups. Conclusions From this study exclusively in the females, it shows that increased LXRα up-regulating ABCG5 and ABCG8 is one defect that leads to hypersecretion of biliary cholesterol and formation of gallstone. ERα may play a role in the formation of gallstone disease in the females, but it requires further study." @default.
- W2391711668 created "2016-06-24" @default.
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- W2391711668 date "2006-01-01" @default.
- W2391711668 modified "2023-09-23" @default.
- W2391711668 title "A study on the difference of hepatic liver X receptor α and estrogen receptor α gene expression between female cholesterol gallstone patients and gallstone free control" @default.
- W2391711668 hasPublicationYear "2006" @default.
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