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- W2391738119 abstract "Objective To study the antidepressant effect of the effective fraction of Sini Powder on mouse depressive model.Methods To establish the depressive model by forced swimming test,tail suspension test,antagonism of reserpine and accentuation of 5-HTP,and the antidepressive effect of the effective fraction of Sini Powder was observed.Result The high-dose of the effective fraction of Sini Powder(600 mg/kg)shortened significantly the time of mouse forced swimming and tail suspension.The high and low doses of the effective fraction of Sini Powder(600mg/kg,300mg/kg)antagonized the descent of body temperature and ptosis induced by reserpine,and increased significantly the frequency of mouse head flick induced by 5-HTP.Conclusion The effective fraction of Sini Powder has a certain antidepressive effect,and can relieve the depressive behaviors of mouse.The mechanism is related to it can increase the content of synaptic monoaminergic neurotransmitter,especially 5-HTP." @default.
- W2391738119 created "2016-06-24" @default.
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- W2391738119 date "2006-01-01" @default.
- W2391738119 modified "2023-09-25" @default.
- W2391738119 title "Effect of effective fraction of Sini Powder on mouse model of behavioral despair and medical depression" @default.
- W2391738119 hasPublicationYear "2006" @default.
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