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- W2391739032 abstract "Objective To explore the potential role of MCP-1/JE in the pathogenesis of severe acute pancreatitis(SAP).Methods SAP was induced by retrograde infusion of 5% sodium taurocholate into the bili-pancreatic duct. Wet to dry weight ratio of pancreas was measured,and pathological changes of the pancreas were observed. Expression of MCP-1/JE gene and protein in rat pancreasis were evaluated by RT-PCR and immunohistochemistry. Results MCP-1/JE protein was detected in pancreatic acinus cells. Compared with that in controls,wet to dry weight ratio of pancreas increased greatly during 12 hours(P 0.01). The expression of MCP-1/JE mRNA in the pancreas was significantly increased(P 0.05 or P 0.01) and was correlated with wet to dry weight ratio of pancreas and the pancreatic damage.Conclusions MCP-1/JE might play an important role in the pathogenesis of SAP." @default.
- W2391739032 created "2016-06-24" @default.
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- W2391739032 date "2004-01-01" @default.
- W2391739032 modified "2023-09-25" @default.
- W2391739032 title "Role of MCP-1/JE in pathogenesis of severe acute pancreatitis" @default.
- W2391739032 hasPublicationYear "2004" @default.
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