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• W2391744449 abstract "Objective:To investigate the effect of LH(Ligustrazine Hydrochloride Injection)on the proliferation promotion and apoptosis inhibition of mice bone marrow stromal cells(BMSCs)induced by VCR(Vincristine).Methods:The BMSCs were cultured with LH(5,10,20,40μg/mL)and VCR(2.5,5,10,15μg/mL)in 37℃5%CO2 for 14 days,respectively and the BMSCs proliferation were determined by MTT.The BMSCs were pretreated by LH(5,10,20,40μg/ml)for 1hour,then cultured with VCR 5μg/ml in 37℃5%CO2 for 14 days,and the BMSCs proliferation were determined by MTT.The BMSCs were cultured for 14 days,then VCR(2.5,5,10,15μg/ml)was added to culture in 37℃5%CO2 for 24hours,respectively,and cell apoptosis was determined by FACS with Annexin V/PI.The BMSCs were cultured with LH(5,10,20,40μg/mL)for 14 days,then 5μg/ml VCR was added to culture in 37℃5%CO2 for 24 hours,respectively,and cell apoptosis was determined by Hoechst 33342 fluorescent staining and FACS with Annexin V/PI.Results:The BMSCs grew more quick along with LH concentration increasing,and the OD value was significantly higher in the LH groups of 20μg/ml and 40μg/ml than in the normal control group on 14th day(P0.05).In the VCR groups the BMSCs grew slower along with VCR concentration increasing,and the OD value was significantly slower in the VCR groups of 10μg/ml and 15μg/ml than in the normal control group in 14th day(P0.05).The BMSCs were pretreated with LH for 1 hour,then cultured with 5μg/ml VCR for 14 days,and proliferation of the BMSCs increased along with LH concentration increasing.In the LH groups of 10μg/ml,20μg/ml,40μg/ml the OD value was significantly higher than in the only VCR 5μg/ml group(P0.05).After the BMSCs were cultured for 14 days,VCR(2.5,5,10 or 15μg/ml)was added to culture and continued to be cultured for 24 hours,then the apoptosis rate of BMSCs detected by FACS with Annexin V/PI was significantly higher in the VCR groups of 5μg/ml,10μg/ml,15μg/ml than in the normal control group(P0.05).After LH culturing with BMSCs for 14 days,5μg/ml VCR was added to culture to continue for 24 hours,then apoptosis rate of BMSCs detected by FACS with Annexin V/PI was significantly lower in the LH groups of 20μg/ml and 40μg/ml than in the only VCR 5μg/ml group(P0.05);and apoptosis rate of BMSCs detected by Hoechst 33342 fluorescent staining was significantly lower in the LH groups of 10μg/ml,20μg/ml and 40μg/ml than in the only VCR 5μg/ml group(P0.05).Conclusion:The results suggested that Ligustrazine can promote the BMSCs proliferation and prevent from inhibition of the proliferation and apoptosis of the BMSCs induced by vincristine." @default.
• W2391744449 created "2016-06-24" @default.
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• W2391744449 date "2010-01-01" @default.
• W2391744449 modified "2023-09-23" @default.
• W2391744449 title "Effect of Ligustrazine Hydrochloride on suppression and apoptosis of bone marrow stromal cells induced by Vincristine" @default.
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