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- W2391746688 abstract "Objective To evaluate the effectiveness and safety of Dapagliflozin for type 2diabetes. Methods eight databases were searched,including Pubmed,Embase,Medline,Cochrane Library,CNKI,WanFang,VIP and CBM.The quality of RCTs was assessed according to the methods of Cochrane systematic review.Meta-analysis was performed using RevMan 5.2software. Results 12 RCTs involving 4914 patients were included.The result of Meta analysis showed that Dapagliflozin relative to placebo provided higher reduction in HbA1c[WMD=-0.58,95%CI(-0.63~-0.53),P0.00001],FPG[WMD=-1.23,95%CI(-1.45~-1.00),P0.00001]and body weight[WMD=-1.77,95%CI(-1.95,-1.58),P0.00001].In aspect of safety,there were no significant differences between them in overall adverse events[RR=1.03,95%CI(0.99~1.07),P=0.09]and Hypoglycaemia[RR=0.96,95%CI(0.74~1.25),P=0.77].Dapagliflozin led to higher incidences of Genital mycotic infections[RR=3.39,95%CI(2.56,4.50),P=0.0007]and Urinary tract infections[RR= 1.45,95%CI(1.17~1.80),P0.00001]compared with placebo. Conclusion Compared with placebo,Dapagliflozin can improve glycemic control,reduce body weight more effectively.Incidences of overall adverse events and hypoglycemia is similar in both Dapagliflozin and placebo groups.Dapagliflozin lead to higher risk of Genital mycotic infections and Urinary tract infections." @default.
- W2391746688 created "2016-06-24" @default.
- W2391746688 creator A5036284015 @default.
- W2391746688 date "2014-01-01" @default.
- W2391746688 modified "2023-09-26" @default.
- W2391746688 title "Clinical comparison of the effects of dapagliflozin and placebo for type 2 diabetes:Systematic review" @default.
- W2391746688 hasPublicationYear "2014" @default.
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