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- W2391768009 abstract "In order to determine the effects of 1 (2,6 dimethylphenoxy) 2 (3,4 dimethoxy phenylethylamino) propane hydrochloride (DDPH 0.1 μmol·L 1 ) on endothelin 1 (ET 1 0.1 μmol·L 1 ) stimulated proliferation of vascular smooth muscle cells (VSMC) and expression of oncogene c myc, c fos, c sis, and antioncogene P53, the experimental models of proliferation of cultured porcine aortic smooth muscle cells induced by ET 1 were established, and thymidine ( TdR) incorporation, flow cytometry, immunohistochem istry and Northern blot assays were used. The results showed that DDPH may drop TdR data increased by ET 1 and hold back VSMC from static phase (G 0/G 1) to DNA synthetic phase (S) and mitotic phase (G 2/M). Furthermore, DDPH could reverse the enhanced expression of oncogene c myc, c fos, c sis and reduced expression of antioncogene P53 induced by ET 1. These results suggest that DDPH may inhibit DNA synthesis and proliferation of VSMC, related with the mechanism of molecular biology of controlling oncogene." @default.
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- W2391768009 date "1997-01-01" @default.
- W2391768009 modified "2023-09-25" @default.
- W2391768009 title "Effects of 1 (2,6 dimethylphenoxy) 2 (3,4 dimethoxyphenyl ethylamino) propane hydrochloride on endothelin stimulated proliferation of vascular smooth muscle cells and expression of oncogenes 1" @default.
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