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- W2391784119 abstract "Objective To observe the variations in superoxide dismutase(SOD) activity and malondialdehyde(MDA) levels in ventilator-induced lung injury(VILI) and the effects of HO-1 expression on SOD and MDA with the establishment of rat model of VILI and the induction of heme oxygenase-1 expression by hemin,and to investigate the protective effect and the underlying mechanism of anti-oxidative stress in VILI.Methods 32 male Sprague-Dawley rats were randomized into 4 groups: control group(tracheotomy only,with spontaneous breathing retained),model group(tracheotomy followed by 4 h of mechanical ventilation),inducer group(intraperitoneal injection of hemin 40 μmol/kg 24 h before model establishment),suppressor group(intraperitoneal injection of ZnPP 10 μmol/kg 24 h before model establishment).4 h after mechanical ventilation,the rats were sacrificed and the lung tissue and samples of bronchoalveolar lavage fluid(BALF) were collected for determination of total protein in BALF,wet-to-dry weight ratio(W/D) of lungs,LDH assaying and the activity of SOD and MDA of lung tissue,detection of lung tissue HO-1 protein expression,and observation of histopathological changes of lungs by light microscopy.Results Compared with the control group,rats in the model group had serious lung histopathological injury and marked increase in W/D of lungs,total protein in BALF and LDH activity,respectively,which suggested the successful establishment of VILI model.In the inducer group,as compared to the model group,HO-1 expression level increased and the lung histopathological injury was significantly attenuated,SOD activity significantly increased while MDA content significantly decreased.With the inhibition of HO-1 expression by ZnPP,this protective effect was reversed.Conclusion Hemin-induced HO-1 expression can increase SOD activity,decrease MDA content,alleviate oxidative stress injury to lung tissues and reduce the extent of VILI." @default.
- W2391784119 created "2016-06-24" @default.
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- W2391784119 date "2010-01-01" @default.
- W2391784119 modified "2023-09-23" @default.
- W2391784119 title "The effect of HO-1 expression on SOD and MDA in ventilator-induced lung injury in rats" @default.
- W2391784119 hasPublicationYear "2010" @default.
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