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- W2391786790 abstract "SUMMARY Objective: To investigate the modification of GABA A receptor subunits in audiogenic seizure rat cortex and hippocampus when rendered tolerant to flurazepam. Methods: Rats were administrated with flurazepam for two weeks, which resulted in tolerance to flurazepam, in the absence of behavioral signs of withdrawal. GABA A receptor subunits α1, α3, α5, γ2L and γ2S were assayed using quantitative competitive RT PCR in rat frontparietal motor(FrPaM) and hippocampus. Results: In FrPaM, the contents of mRNA encoding for α1, α3, γ2L and γ2S were all significantly decreased (24%,17%,35% and 45% respectively),whereas that of α5 was significantly increased (33%) compared with the control. In hippocampus, α1, γ2L, and γ2S mRNA contents were significantly decreased (33%, 35%and 27% respectively). Conclusion: The accomodated change in GABA A receptor subunits α1, α3, α5,γ2L and γ2S in FrPaM and hippocampus may be associated with the mechanism of flurazepam tolerance in audiogenic seizure rats." @default.
- W2391786790 created "2016-06-24" @default.
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- W2391786790 date "2001-01-01" @default.
- W2391786790 modified "2023-09-25" @default.
- W2391786790 title "Modification of GABA _A receptor subunit mRNA content in audiogenic seizure rat cortex and hippocampus following tolerance to flurazepam" @default.
- W2391786790 hasPublicationYear "2001" @default.
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