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- W2391791245 abstract "Objective To study the cerebral metabolism of the motor circuit and anterior cingulate circuit closely associated with Tourette syndrome (TS) and observe their metabolic changes following pallidotomy. Methods Six patients with TS receiving pallidotomy underwent examination with positron emission tomography with 18-fluorodeoxyglucose (FDG-PET) 1 week before and 3 months after operation respectively, to evaluate the changes in the metabolic rate of the motor and anterior cingulated circuits in comparison with normal control subjects. The radioactivity ratio (RAR) in the areas with metabolic abnormalities in the two circuits was measured, and compared with the same areas in normal control subjects. The severity of the symptom was assessed in relation to RAR. Results Before operation, hypermetabolism was observed in the cortical regions in the motor circuit, whereas hypometabolism was detected in the cingulate cortex, temporal neocortex and caudate of the anterior cingulate circuit. The hypermetabolic areas in the motor circuit were decreased after the operation, but the hypometabolic areas remained unchanged in the anterior cingulated circuit. The Yale Global Tic Severity Scale (YGTSS) scores were found to relate to RAR. Conclusions Hypermetabolism in the cortical structures of the motor circuit and hypometabolism of the anterior cingulated circuit defined by PET characterize patients with TS. Abnormal metabolism in the two circuits may constitute the pathophysiological basis of TS. Pallidotomy serves as an effective intervention to regulate the abnormal metabolism in the two circuits." @default.
- W2391791245 created "2016-06-24" @default.
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- W2391791245 date "2005-01-01" @default.
- W2391791245 modified "2023-09-25" @default.
- W2391791245 title "Effect of pallidotomy on cerebral metabolism in patients with Tourette syndrome" @default.
- W2391791245 hasPublicationYear "2005" @default.
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