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- W2391842004 abstract "The effects of tea polyphenol (TP) and its main components,(-)epicatechin (EC), (-)epicatechin gallate(ECG), epigallocatechin (EGC) and (-)epigallocatechin gallate (EGCG) with caffeine on reversion of tumor multidrug resistance (MDR) are investigated by using MCF7/Adr cell line and 99TcmMIBI as a substrate of Pglucoprotein(Pgp). MCF7/Adr cells are incubated with 99TcmMIBI in the presence or absence of TP or its main components (separate or mixed). The cell uptake of 99TcmMIBI is measured and compared with a contrast to estimate the MDR reversion effect.The experimental results indicate that the native tea polyphenol exhibits a moderate MDR reversion effect. The MDR reversion efficacies of the four main components of TP are found in the sequence ECGEGCECEGCG. Caffeine as well as the mixture of EGCGECGEGCEC in the mass ratio 10∶3∶2∶1 shows practically no MDR reversion effect." @default.
- W2391842004 created "2016-06-24" @default.
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- W2391842004 date "2003-01-01" @default.
- W2391842004 modified "2023-09-25" @default.
- W2391842004 title "EFFECTS OF TEA POLYPHENOL COMPONENTS ON REVERSION OF TUMOR MULTIDRUG RESISTANCE" @default.
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