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- W2391878982 abstract "Objective To evaluate the diagnostic values of serum CYFRA21-1,NSE and CEA levels determination in patients with non-small lung cancer(NSCLC).Methods Serum concentrations of NSE,CEA and CYFRA21-1 were measured in 178 patients with NSCLC,98 patients with benign lung diseases(BLD) and 166 healthy persons.CEA was measured by chemiluminesent microparticle Immunoassay on ARCHITECT i2000sr.CYFRA21-1 and NSE were measured by electrochemiluminescence immunoassays on the Roche Elecsys 2010.Results The serum concentrations of these three tumor markers were significantly higher in the NSCLC patients than in the healthy people and BLD patients When the healthy people were used as the reference group and the specificity was 95%,the cutoff points of CYFRA 21-1,CEA and NSE were 2.23 μg/L,3.98 μg/L and 20.39 μg/L respectively.At these points,the diagnostic sensitivities for NSCLC were CYFRA21-1 63.5%,CEA 47.8%,NSE 29.2%,respectively.When the reference group was replaced with BLD patients,the cutoff points were elevated to 3.26 μg/L,5.51 μg/L and 26.14 μg/L respectively and the diagnostic sensitivities were reduced to 48.9%,16.3% and 39.3% respectively.For squamous cell carcinoma(SQC),CYFRA21-1 was the most sensitive tumor marker(66.2%) and so was CEA for adenocarcinoma(53.3%).The positive rates of NSE in the NSCLC ranged from 13.0% to 20.3%.Receiver operating curve demonstrated that CYFRA21-1 was the most valuable tumor marker for the differential diagnosis of BLD and NSCLC.Conclusion CYFRA 21-1 was of the most value for the diagnosis of NSCLC,especially squamous cell carcinoma.CEA was the most valuable tumor marker for adenocarcinoma.There is little usefulness in diagnosing NSCLC for NSE." @default.
- W2391878982 created "2016-06-24" @default.
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- W2391878982 date "2009-01-01" @default.
- W2391878982 modified "2023-09-22" @default.
- W2391878982 title "Evaluating the diagnostic values of serum CYFRA21-1,NSE and CEA levels determination in patients with non-small lung cancer" @default.
- W2391878982 hasPublicationYear "2009" @default.
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