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- W2391888373 abstract "Objective To research the difference in degrees of acute liver damage in mice models caused by carbon tetracholoride (CCl 4) with 3 routes of administration, e.g.ig, sc and ip. Methods Sixty of the Kunming mice were casually divided into six groups (n=10), including three liver damage groups and three normal groups. The carbon tetracholoride were given through ig, sc, ip. At 24h after injection, each mice of all the six groups was injected 0.1 ml·10g -1 of 0.4% thiopental sodium through ip. The maintain time of anaesthesia was observed, then the mice was killed. The liver of animal pattern with naked eyes and pathological histology test was observed. Results Both ig and sc could cause acute liver damage of mice by CCl 4, and the degree of liver damage in both groups was higher than that of the normal group (P0.01). Conclusion The preparation method of acute liver damage mice models caused by CCl 4 can be made by choosing ig and sc according to the different medicines studied." @default.
- W2391888373 created "2016-06-24" @default.
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- W2391888373 date "2001-01-01" @default.
- W2391888373 modified "2023-09-25" @default.
- W2391888373 title "Research on the preparation method of acute liver damage mice model caused by carbon tetracholoride poisoning" @default.
- W2391888373 hasPublicationYear "2001" @default.
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