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- W2391901869 abstract "Proteasome pathway is another major pathway of protein degradation in addition to lysosome in eukaryotic cell,which involved a number of physiological functions regulation in cell.Prokaryotic ubiquitin-like protein was found in Mycobacterium tuberculosis in 2008.With the effect of co-factor Dop,PafA and Mpa,Pup can mark a variety of protein ubiquitination followed by importing them into proteasomal degradation.The target protein of Pup-proteasome system like FabD,PanB,Ino1,Icl,SodA,and MtrA are involved with metabolism,signal transduction pathways,virulence factors,pathogenicity and the persistence of bacteria in the host cell.Proteasome inhibitor make the function of proteasome restricted and the accumulation of Pup's labeled substrate result in changes in the expression of gene indirectly,which impacted the ability of resistance to outside pressure and the pathogenicity of Mycobacterium tuberculosis.The finding Pup-proteasome system reveals a novel mechanism of protein degradation in prokaryotes,which is expected to become a new target of treatment of anti-TB drugs.Here,we summarize the progress on the Pup-proteasome system in Mycobacterium tuberculosis." @default.
- W2391901869 created "2016-06-24" @default.
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- W2391901869 date "2014-01-01" @default.
- W2391901869 modified "2023-09-24" @default.
- W2391901869 title "Study progress of prokaryotic ubiquitin-like protein(Pup)-proteasome system of Mycobacterium tuberculosis" @default.
- W2391901869 hasPublicationYear "2014" @default.
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