Matches in SemOpenAlex for { <https://semopenalex.org/work/W2391923786> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2391923786 abstract "Objective To explore the effects of quorum-sensing system on CD4+CD25+ Treg cell in Pseudomonas aeruginosa.Methods Sixty SD rats were divided into 3 groups: PAO1 group,PAO-JP2(lasI and rhlI double mutant) group,and control group.Chronic lung infection model was set up by placing P.aeruginosa-precoated silicone tube into the main bronchus.Twentyeight days later,The Treg cell in venous blood,the IL-10 and TGF-β in serum,and the Foxp3mRNA in spleen were detected by FACs,ELISA,and RT-PCR,respectively.The pulmonary tissues were stained with HE.Results 1) Treg/CD4+T for PAO1 group was(19.79±6.45)%,which was significantly higher than those of JP2 group(11.03±3.92)% and control group(5.15±0.47)%(P0.05).2) The levels of IL-10 and TGF-β were(231.52±54.48) pg/mL and(121.05±7.98) pg/mL for PAO1 group,(60.10±29.64) pg/mL and(63.11±5.73) pg/mL for JP2 group,while(35.43±23.56) pg/mL and(36.02±8.94) pg/mL for control group.Compared with JP2 and control group,PAO1 group expressed much more cytokines(P 0.05).3) As Foxp3mRNA expression,PAO1 group(0.80±0.044) was higher than JP2 group(0.41±0.044) and control group(0.25±0.054)(P0.05).4) The pathological changes: fibrinous adhesions and granulomas could be found in lungs of PAO1 infected groups.At optical microscopy,PAO1 caused a pronounced inflammatory reaction with lymphocytes.For JP2 group,milder inflammatory change was detected.Conclusion Quorum-sensing system up-regulates CD4+CD25+ Treg cell through enhancing the expression levels of IL-10,TGF-β,and Foxp3mRNA,thus which plays an important role in chronic lung infection by Pseudomonas aeruginosa." @default.
- W2391923786 created "2016-06-24" @default.
- W2391923786 creator A5038349950 @default.
- W2391923786 date "2009-01-01" @default.
- W2391923786 modified "2023-09-28" @default.
- W2391923786 title "Effects of quorum-sensing system on CD4~+CD25~+Treg cell in Pseudomonas aeruginosa" @default.
- W2391923786 hasPublicationYear "2009" @default.
- W2391923786 type Work @default.
- W2391923786 sameAs 2391923786 @default.
- W2391923786 citedByCount "0" @default.
- W2391923786 crossrefType "journal-article" @default.
- W2391923786 hasAuthorship W2391923786A5038349950 @default.
- W2391923786 hasConcept C104317684 @default.
- W2391923786 hasConcept C118687296 @default.
- W2391923786 hasConcept C126322002 @default.
- W2391923786 hasConcept C142724271 @default.
- W2391923786 hasConcept C203014093 @default.
- W2391923786 hasConcept C2777637488 @default.
- W2391923786 hasConcept C2777714996 @default.
- W2391923786 hasConcept C2780931953 @default.
- W2391923786 hasConcept C523546767 @default.
- W2391923786 hasConcept C54355233 @default.
- W2391923786 hasConcept C55493867 @default.
- W2391923786 hasConcept C60987743 @default.
- W2391923786 hasConcept C71924100 @default.
- W2391923786 hasConcept C86803240 @default.
- W2391923786 hasConcept C89423630 @default.
- W2391923786 hasConcept C90924648 @default.
- W2391923786 hasConceptScore W2391923786C104317684 @default.
- W2391923786 hasConceptScore W2391923786C118687296 @default.
- W2391923786 hasConceptScore W2391923786C126322002 @default.
- W2391923786 hasConceptScore W2391923786C142724271 @default.
- W2391923786 hasConceptScore W2391923786C203014093 @default.
- W2391923786 hasConceptScore W2391923786C2777637488 @default.
- W2391923786 hasConceptScore W2391923786C2777714996 @default.
- W2391923786 hasConceptScore W2391923786C2780931953 @default.
- W2391923786 hasConceptScore W2391923786C523546767 @default.
- W2391923786 hasConceptScore W2391923786C54355233 @default.
- W2391923786 hasConceptScore W2391923786C55493867 @default.
- W2391923786 hasConceptScore W2391923786C60987743 @default.
- W2391923786 hasConceptScore W2391923786C71924100 @default.
- W2391923786 hasConceptScore W2391923786C86803240 @default.
- W2391923786 hasConceptScore W2391923786C89423630 @default.
- W2391923786 hasConceptScore W2391923786C90924648 @default.
- W2391923786 hasLocation W23919237861 @default.
- W2391923786 hasOpenAccess W2391923786 @default.
- W2391923786 hasPrimaryLocation W23919237861 @default.
- W2391923786 hasRelatedWork W2350705621 @default.
- W2391923786 hasRelatedWork W2351093754 @default.
- W2391923786 hasRelatedWork W2351214801 @default.
- W2391923786 hasRelatedWork W2351927137 @default.
- W2391923786 hasRelatedWork W2355734840 @default.
- W2391923786 hasRelatedWork W2355972405 @default.
- W2391923786 hasRelatedWork W2356614291 @default.
- W2391923786 hasRelatedWork W2357688602 @default.
- W2391923786 hasRelatedWork W2363114483 @default.
- W2391923786 hasRelatedWork W2367947760 @default.
- W2391923786 hasRelatedWork W2373863820 @default.
- W2391923786 hasRelatedWork W2382663618 @default.
- W2391923786 hasRelatedWork W2391224776 @default.
- W2391923786 hasRelatedWork W2393030171 @default.
- W2391923786 hasRelatedWork W2716084 @default.
- W2391923786 hasRelatedWork W2752119684 @default.
- W2391923786 hasRelatedWork W2766192850 @default.
- W2391923786 hasRelatedWork W2930856210 @default.
- W2391923786 hasRelatedWork W3031571701 @default.
- W2391923786 hasRelatedWork W3031654899 @default.
- W2391923786 isParatext "false" @default.
- W2391923786 isRetracted "false" @default.
- W2391923786 magId "2391923786" @default.
- W2391923786 workType "article" @default.