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- W2391929217 abstract "Objective: To study the effect of fluoroquinolone drug levofloxacin(LVFX)on delayed rectifier potassium current(IK) of guinea pig ventricular myocytes.Methods: Single guinea pig ventricular myocyte was isolated using digestive enzyme,effects of different concentrations of LVFX on delayed rectifier potassium current(IK) of guinea pig ventricular myocytes were studied using whole-cell patch clamp recording technique.Results: ①Pulse current and tail current of IK were inhibited by SPX and LVFX with concentrations dependence,but its original voltage and time-dependent were not affected.②On the condition that the concentrations of LVFX were 0.1,1,10,100,1 000 μM,and +50 mV depolarization voltage,compared with the control group for IK in this study,the pulse current reduced by(11.81 ± 1.71)%,(14.51 ± 2.12)%,(22.78 ± 3.58)%,(29.59 ± 2.89)%,(38.13 ± 2.44)%,respectively;tail current decreased by(6.05 ± 2.51)%,(12.19 ± 1.49)%,(17.75 ± 2.74) %,(30.05 ± 1.49)%,(48.18 ± 3.71)%,respectively.Conclusion: LVFX of different concentrations have different degrees of inhibitions on the delayed rectifier potassium current(IK) of guinea pig ventricular myocytes." @default.
- W2391929217 created "2016-06-24" @default.
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- W2391929217 date "2008-01-01" @default.
- W2391929217 modified "2023-09-24" @default.
- W2391929217 title "Effect of levofloxacin lactate on delayed rectifier potassium current of guinea pig ventricular myocytes" @default.
- W2391929217 hasPublicationYear "2008" @default.
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