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- W2391940469 abstract "Objective:To analyze the polarization state of peripheral blood T cells subsets of patients with ankylosing spondylitis(AS) and illuminate the immunologic pathogenesis.Methods:CD3+CD4+CD30+,CD3+CD4+CD30-,CD3+CD8+CD30+,CD3+CD8+CD30-T cells in peripheral blood of patients with AS and healthy controls was detected in CD3/CD4 or CD3/CD8 subsets by flow cytometry in order to reflect Th1/Th2,Tc1/Tc2 bins.Results:Compared with healthy control, the average percentage of CD4+T cells and the ratios of CD4+T/CD8+T in early stage of AS were decreased obviously (P0.05),and the average percentage of Th1 cells as well as the ratios of Th1/Th2 were decreased obviously(P0.05).Meanwhile the average percentage of CD8+T cells and Tc2 cells increased sharply(P0.05). In advanced period, the average percentage of Tc2 increased sharply and the ratio of Tc1/Tc2 were decreased obviously (P0.05).Conclusion:The changes of CD4+,CD8+T cells,CD4+T/CD8+T in early stage of AS are significant compared with controls, which indicates the disorder of immunofunctions.The changes suggest that the Th1/Th2 and Tc1/Tc2 are of imbalance in early stages of AS and Th2,Tc2 are predominant. In advanced stages of AS, the ratio of Tc1/Tc2 decreased obviously with Tc1/Tc2 imbalance.It is implied that the imbalance of Th1/Th2,Tc1/Tc2 might play an important role in AS and be involved in the pathogenesis of AS." @default.
- W2391940469 created "2016-06-24" @default.
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- W2391940469 date "2007-01-01" @default.
- W2391940469 modified "2023-09-25" @default.
- W2391940469 title "Study of the polarization state of peripheral blood T cell subsets of patients with ankylosing spondylitis" @default.
- W2391940469 hasPublicationYear "2007" @default.
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