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- W2391946896 abstract "To observe the change of Th1(IFN-γ) and Th2(IL-4) cytokines in lymph,and to compare their levels in bronchoalveolar lavage fluid(BALF) and plasma of asthmatic rat,the rat-asthmatic model were established,and the levels of IL-4,IFN-γ and IL-12 in lymph,BALF and plasma were detected by enzyme linked immunosorbent assay(ELISA) after challenge with ovalbumin in 0,2,6,10,24,48 hours in asthmatic and control rats.It was found that the levels of IL-4,IFN-γ and IL-12 in lymph were significantly higher than those in BALF and plasma after challenging in 0,2,6,10,24,48 hours in asthmagtic and controls(P0.01).In the ashmatic group of rats,the levels of IL-4,IFN-γ and IL-12 in lymph 2,6,10,24,48 hours after challenge were significantly higher than those in 0 hr(P0.05).The level of IL-4 in lymph increased to the maximal level at 10 hour,while that in BALF and plasma increased to the maximal level at 24 h.IFN-γ and IL-12 in lymph increased to the maximal level at 6 hour,and those in BALF and plasma increased to the maximal level at 10 hour.The level of IL-4 in lymph of asthmatic rats was significantly higher than that in controls,and the levels of IFN-γ and IL-12 were significantly lower than that in controls.It is evident that the concentration of IL-4,IFN-γ and IL-12 in lymph,BALF and plasma were alike reduced from high to low levels in asthmatic and control rats.The maximal levels of IL-4,IFN-γ and IL-12 in lymph appeared to be early emerged than those in BALF and plasma.From these observations,it suggests that the Th1/Th2 unbalance impressing Th2-hyperfunction exists in lymph of ashmatic rats,and the cytokines level in lymph can reflect the degree of the asmatic inflammation much early and accurately." @default.
- W2391946896 created "2016-06-24" @default.
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- W2391946896 date "2009-01-01" @default.
- W2391946896 modified "2023-09-25" @default.
- W2391946896 title "The change of Th1/Th2 cytokines in lymph and comparison of these cytokines in lymph,BALF and plasma in bronchial asthma rat" @default.
- W2391946896 hasPublicationYear "2009" @default.
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